Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes

The TRPV3 calcium ion channel is vital for maintaining skin health and has been associated with various skin-related disorders. Since involved in the development of inflammation, inhibiting could be a potential treatment strategy. Alpha-mangostin isolated from Garcinia mangostana L. extract exhibits diverse positive effects on health; however, underlying mechanisms remain obscure. This study investigated TRPV3-inhibitory properties alpha-mangostin hyperactive mutants Olmsted syndrome its impact TRPV3-induced cytokine secretion cell death. Our findings demonstrate that effectively inhibits TRPV3, an IC50 0.077 ± 0.013 μM, showing inhibitory both wild-type mutant TRPV3. inhibition decreased influx release, protecting cells These results indicate reduced inflammation TRPV3-activated keratinocytes, suggesting potentially used improving inflammatory conditions such as dermatitis.